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12. Genes

<p>source : <cite>www.<strong>winwellness</strong>.org</cite><br /><strong><em></em></strong><br /><strong>“But I’ve Got Bad Genes!”</strong><br /> Genes<br />          </p> <p>  </p> <p> <strong>PowerPoint© Slide 1</strong><br /><strong>“But I’ve Got Bad Genes!”</strong><br /> Genes</p> <p> <br /> The topic of genetics is extremely important, since it can affect your life positively. Although it is more scientific than are most chapters, the information is valuable and can be life saving.<br />  <br /> Julia was leaving one afternoon for a weekend with her adult daughter in the big city, when she remembered her appointment to have a mammogram. <em>I would like to cancel it, but I’ll just breeze in and have it done at the clinic, </em>she thought, <em>and we’ll be on our way.</em><br />  <br /> The mammogram was finished and she was putting on her clothes when the X-ray technician asked for a second X-ray and a third. Julia went on her way somewhat apprehensively. Several hours later she received a phone call. “Julia, this is Dr. Newmeyer. The radiology reports are in, and we have concerns about the small lump on your left breast. It has changed in size and density. I’d like to have you come to the clinic Monday for a biopsy.” The weekend had taken an unexpected turn.<br />  <br /> Monday morning, Julia sat motionless and stunned. Her primary-care physician spoke. “Can we review the cancer history of your family?” “Yes,” she sadly answered, “I guess I should have expected this. My mother had breast cancer, and my Aunt Nell died of cancer complications. My cousin had a mastectomy. I might have known. It seems to be in our family genes.” <em>What can I do? </em>she thought. <em>My daughter is probably predestined to the same fate.</em> Later the biopsy report showed that Julia did have breast cancer.<br />  <br /> Was Julia’s cancer an inevitable result of inherited genes? Had she simply been “dealt a bad hand”? What about you? In the back of your mind, do you wonder if or when you will get that phone call from your doctor?<br />  <br /> When there has been a persistent history of family breast cancer, some have undergone genetic testing for specific cancer genes. This is what Lyn did at age twenty-nine. The results revealed a 70 percent likelihood of eventually her getting the most lethal form of breast cancer known. What were her options? She could have a bilateral mastectomy. She could try to change her gene expression and, by adjusting her lifestyle, turn <em>off</em>the lethal cancer gene that ran in her family. Whichever option she chose, she needed tobe absolutely serious about it and have close medical supervision.<br />  <br /><strong>“Whatever will be, will be”orwillit?</strong><br /> In the world today, there are people who believe that they are made to be what they are, that there is nothing they can do about it. Some thieves say they have been made to be thieves. Some assassins feel they were naturally programmed to kill. But are people truly made to be thieves or killers? Are we all programmed to be what we are?<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 2</strong><br /><strong>“Quéserá, ser</strong><strong>á—Whatever will be, will be”</strong><br /> Do you believe that?</p> <p> <br /> A few years ago the song, “QuéSerá, Será,” made it to number two on the US charts and received an Oscar award. But the song suggests that our future is predetermined and there’s not much we can do about it. Do you believe that?<br />  <br /><strong>Predetermined?</strong><br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 3</strong><br /><strong>Predetermined?</strong></p> <p> <br />  <br /> Many people think that our health and many other aspects of our lives boil down to fate—that they are a result of our genetic makeup. But your genes are not your destiny. Often, we hear people say, “Oh, my mom has diabetes, so I’ll probably get it too.”<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 4</strong><br /> Most disease promoting genes do determine a predisposition for disease but they do not determine disease itself.  It is the choices we make consciously or unconsciously that largely determine our future health. <br />  </p> <p> <br /> In close physical proximity to a given gene are small markers called epigenes (“epi” means upon, above, or over). These can be changed by our lifestyle habits. They are not genes themselves, but they are on/offswitches that can turn off a cancer, diabetes, or heart disease gene. They determine which genes will express themselves.<br />  <br /> In Shakespeare’s famous play <em>Julius Caesar, </em>he quotes Cassius as saying that our fate, “dear Brutus, is not in our stars, but in ourselves.” Yes, our fate is not determined by horoscopes, the star under which we were born, or even by our genes. It is our daily choices that largely determine our future. We are the architects of our own destiny.<br />  <br /><strong>Thestoryofidenticaltwins</strong><br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 5</strong><br /> Ana Marie and Clotilde, age 66<br />  </p> <p> <br /> Ana Marie and Clotilde, born in 1942, are identical twins living in Spain. They have exactly the same genes. They have the same facial expressions, laugh alike, and often dress alike for interviews without consulting each other. They are literally clones of each other. So they’ll probably contract the same diseases, right? Wrong! Ana Marie has contracted cancer. Clotilde is in vibrant health. What makes the difference? It certainly is not the genes, because they are identical. But their lifestyles have been very different.<br />  <br /> Lifestyle affects certain carbon-hydrogen chemical tags called methyls and histones. Methyls grab onto the DNA. Histones grab onto gene proteins and they throw the switch, largely determining whether the gene will be expressed or not. They are part of what scientists call the <em>epigenome</em>.<a href="#_edn1" name="_ednref1" title="" id="_ednref1">[1]</a> Generally, methyls silence the genes and histones activate genes.<a href="#_edn2" name="_ednref2" title="" id="_ednref2">[2]</a><br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 6</strong><br /><strong>DNA Methylation Differences</strong><br /> Pictured here are the epigenomes of identical twins. In column 2 you will note that at age 3 the epigenomes are substantially the same. In column 4 note there are considerable differences between twins at age 50.<br />  </p> <p> <br /> Geneticists have studied the epigenomes of identical twins and found them to be substantially similar at the age of three. However, by age fiftythe epigenome differences in twins have increased four-fold.<a href="#_edn3" name="_ednref3" title="" id="_ednref3">[3]</a>This means that, although their genes remained the same throughout life, many of the epigenes that throw the on-off switches on the genes were quite different. Their heredity was the same, but lifestyle and environmental differences caused a change in gene expression.<br />  <br /><strong>Youmaketheultimatehealthdecisions</strong><br /> When a father and mother parent a child, each parent passes twenty-threechromosomes to the offspring. But they also pass on epigenome settings determining which gene switches are turned onand which are turned off. However, as the child matures, he or shewill rearrange the settings by choices of lifestyle. Can you imagine how terrific it would be if most, or all, of the inherited bad genes were turned off—such as <em>off</em>with the diabetes gene, <em>off</em>with the cancer genes—and all or most of the inherited good genes were turned <em>on</em>?<br />  <br /><strong>Millieand her genes</strong><br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 7</strong><br /><strong>Millie and her genes</strong><br /> Millie (co-author of WIN! Wellness)and her brother George a year before the deaths of their parents.<br />  </p> <p> <br />  <br /> One day when I was nine and my brother George was eleven,we lingered uneasily near the bedroom door at the old home place. Inside,our mother lay in a diabetic coma. She had not spoken for several days. We were told to be very quiet because she was extremely sick. Insulin had been discovered but was not yet used in ourhometown and became available too late to save our beloved mother. The physician came out from the bedroom, his face serious. “She’s gone,” he whispered. It was a moment that would change my life forever.<br />                                                         <br /> Only years later would I run across a letter my mother had written, describing her ocean voyage to the New World, when she emigrated from what was then Czechoslovakia to Texas, USA. Perhaps it was the rich meals that had been showered on her at her farewells and sweet <em>kolache</em> pastries that she took along for the long voyage that caused her illness. The letter described how sick she was—probably her first diabetic coma. She specifically said that it was not sea sickness.<br />  <br /> Six weeks after Mother’s death, my father was putting on his clothes, getting ready for work at the saddle shop that he owned. Suddenly he clutched his chest. “Call the doctor!”he shouted. I picked up the telephone receiver and fumbled to find the number. The doctor arrived quickly and rushed to the porch bedroom where Father lay. Thirty minutes later he came out and said, “He’s gone. Heart attack!” My brother George and I were orphans.<br />  <br /> A diabetes gene must have been waiting for the next generation. When George was sixty-twoand hospitalized for a serious health problem, he was diagnosed with the dreaded disease. Being an active electrician who worked hard, with walking as part of his daily work and following the diabetic diet recommendations, his diabetes was held under control. He did have to take insulin.He was extremely careful about not eating sweet items, and he cut down on eating starchy carbohydrate foods. Brother George did a lot of the right things, which lengthened his life to a good age of eighty-three.<br />  <br /> My mother died at age thirty-sevenand my father at age forty-seven. With all the current research and information on diabetes and heart disease, I have often thought that both did not have to die so young. I could have enjoyed them for many years, but they did not have the knowledge that we have today. They could have lived more fruitful years and enjoyed life to the fullest, as did their son, George. My parents didn’t know what you will know from reading this book. Even George perhaps could have lived longer with an improved lifestyle at his older age. He did suffer circulatory problems in his legs that contributed to his death.<br />  <br /> Our lifestyle makes a difference and helps to prevent disease, pain, extra medical appointments, and excessive doctor bills. Lifestyle changes the epigenes and, in many cases, throws the diabetic gene switch to the <em>off</em>position. The way we live has a lot to do with the way we die.<br />  <br />  <br />  <br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 8</strong><br /><strong>70% of the outcome depends on you</strong><br /> Whether you have chronic disease or vibrant health depends about 70% on your lifestyle epigenome and less than 30% on your medical care, DNA sequence, and non-epigenome environment.<br />  </p> <p> <br /> So when you change your diet and lifestyle, that changes your epigenome, which changes your gene expression, and that literally changes you!<a href="#_edn4" name="_ednref4" title="" id="_ednref4">[4]</a><br />  <br /> Epigenetics is proving we have some responsibility for the integrity of our genome. Before, genes predetermined outcomes. Now everything we do—everything we eat or smoke—can affect our gene expression and that of future generations. Epigenetics introduces the concept of <em>free will</em> into our idea of genetics.<a href="#_edn5" name="_ednref5" title="" id="_ednref5">[5]</a><br />  <br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 9</strong><br /> If our genes are the “cards we are dealt,” then epigenetics is how we play them.</p> <p> <br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 10</strong><br /><strong>Prostate Cancer and Genetics</strong></p> <ul><li> Can I modify how my genes express themselves?</li> <li> Absolutely!</li> </ul><p>  </p> <p> <br />  <br /><strong>Gene expressionchanged in low-levelprostatecancer in threemonths</strong><br /> Exciting new research published by Dr. Dean Ornish<a href="#_edn6" name="_ednref6" title="" id="_ednref6">[6]</a> found conclusive evidence that can bring hope to men suffering from low-level prostate cancer. Biopsies taken at the beginning and end of the study demonstrated significant changes.<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 11</strong><br /><strong>Gene Expression changed in low-level Prostate Cancer in 3-months</strong><br /> The LIFESTYLE THERAPY USED:</p> <ol><li>  A Plant-based diet</li> <li>  Moderate Exercise</li> <li>  Stress management techniques</li> <li>  A weekly support group</li> </ol><p>                        <br /> Dr. Dean Ornish, University of Calif. at San Francisco, <em>Proceedings of the National Academy of Sciences</em>, June 28, 2008<br />  </p> <p> <br /> Before starting the lifestyle medicine program, 453 cancer and disease-promoting genes were all in the <em>on</em>position and forty-eightcancer-preventing genes were all in the <em>off</em>position. But after three months of eating an optimal diet, exercising daily, following stress management strategies, and attending a group support program, all 453 cancer and disease-promoting genes changed from the <em>on</em>to the <em>off</em>position. The previously inactive cancer prevention genes were also all changed to the <em>on</em>and active position.<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 12</strong><br /><strong>EPIGENETICS</strong><br /> ACTIVATION<br /> Cancer Fighting Genes<br />    48 turned ON<br /> INACTIVATION<br /> Cancer Promoting Genes<br /> 453 turned OFF<br /> Expression changed on 501 genes<br />  <br />  </p> <p> <br /> Collateral changes were noted from this lifestyle treatment. The individuals lost weight, decreased their ratio of fat to body mass (BMI), lowered the upper reading on their blood pressure by an average of 9.2 mm of mercury, lowered theirtotal cholesterol by 45 points, and their LDL cholestrol by 34.2 mg/dL. That was a real “make-over” in just three months!<br />  <br />  <br /> This is a profoundly hopeful message. This study is the first to show the effect of lifestyle changes on any kind of cancer genes. We hope it will motivate people to begin making their own changes by choice. Ornish states,<br />  <br /> In most cases, our genes are only a predisposition [tendency]; they are not written in stone. And if we have a strong family history for diseases such as prostate cancer, breast cancer, or heart disease—“bad genes”—then we may need to make bigger changes in lifestyle in order to help prevent or even reverse chronic diseases. . . . It’s not all in our genes.<a href="#_edn7" name="_ednref7" title="" id="_ednref7">[7]</a><br />  <br /> Choices have a powerful effect!<br />  <br /><strong>Telomeres, stress, and aging </strong><br />  <br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 13</strong><br /><strong>Telomeres, stress, and aging</strong><br /> Usually a short tail on chromosomes means that they are aging.  Do you want longer telomeres?<br />  </p> <p> <br />  <br /> On the end of every chromosome is a tail or end-cap called a <em>telomere</em>. Scientists have found that when the chromosome reproduces, part of the telomere tail gets shortened. This shortening is related to the aging of the organism. The telomere can only copy itself about fiftytimes. One main resource to enhance the health of the telomere and to protect the chromosome from damage is the enzyme <em>telomerase</em>, which helps repair the telomere and keep it optimally elongated.<br />  <br /> Nobel Prize winner Elizabeth Blackburn discovered the enzyme <em>telomerase</em>. She states that keeping the tips of chromosomes healthy is key to preventing the formation of early cancer cells and slowing the aging process. She explains, “Chronic severe psychological stress makes them [the telomeres] wear down.”<a href="#_edn8" name="_ednref8" title="" id="_ednref8">[8]</a><br />  <br /> Stresses such as caring for a parent with Alzheimer’sorfear of losing a job affect the genetic process. Even the plunging economy is literally making people sick. What do you do about high stress? Exercise, quiet time with God in prayer, and letting Him speak to you in His Word are keys to preventing or relieving stress. These remedies can calm our nerves and can be more helpful than tranquilizers.<br />  <br /> Katie was sent to the hospital during an economic recession. Her income had been cut 20 percent and her workload increased. She was falling behind on her house payments and feared that her house might be repossessed. Forced to get a second part-time job, her emotional stress increased. Her physical symptoms included panic attacks, crying, sleeplessness, and low energy. Not only was her depression pouring an excess of negative stress hormones into her bloodstream, but long term it was undoubtedly cutting back on her telomerase enzyme and setting her up for possible cancer in the future. So what might help her to release her inward stress tension and prevent physical harm to her body? Walk—walk—walk and pray—pray—pray. She must change her lifestyle.<br />  <br /> Dr. Ornish’s groundbreaking research showed another astounding resultthat those following his lifestyle program including a proper diet and exercise increased their body’s production of <em>telomerase</em>by 30%. They could live a greater quality life and postpone their own funeral. Katie also had the potentialto change in lifestyle and repair her telomeres. Her integrated balanced living, including a nutritious diet, could thus protect her chromosomes from premature aging. <a href="#_edn9" name="_ednref9" title="" id="_ednref9">[9]</a><br />  <br /><strong>Thefatyellow mouse story</strong><br /> I would like to have you meet a fat yellow mouse we’ll call Guti.<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 14</strong><br /> The Fat Yellow Mouse Story</p> <p> <br /> Her sister is lean, fast, and has a brown coat. We’ll call her Cuti.<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 15</strong><br /> They are identical twins!</p> <p> <br />  Their genes are exactly the same. But the one with the dark brown coat is lively and strong, while her sister is fat and has a yellow coat. Why the difference? Guti was fed on junk food, will develop diabetes and heart disease, and will die of cancer. Cuti ate supernutrients and will have a long, healthy mouse life. While both sisters had exactly the same disease-causing genes, Cuti’s diet “flipped the switch,” turning offthe disease-causing genes.<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 16</strong><br /><strong>Genetically identical but healthwise very different!</strong></p> <p> <br /> Science is discovering more and more health factors which “flip the switch” turning disease preventing genes on, or not incorporated into the lifestyle, turning disease-causing genes on.<br /><strong>Sleep deprivation sparks changes in expression of 224 genes</strong></p> <p>  </p> <p> <strong>PowerPoint© Slide 17</strong><br /> Sleep Deprivation Sparks Changes in Expression of 224 Genes                               <br />  </p> <p> <br /> But it is not just Dr. Ornish’s factors of diet, exercise, stress management, and social support that activate good genes. Other lifestyle factors can change gene expression. Adequate rest is one of these. The Allen Institute for Brain Science, in collaboration with SRI International, reports that 224 genes in mice show a changed expression due to sleep deprivation and that thousands of genes appear to be regulated by the twenty-four-hour circadian rhythm.<a href="#_edn10" name="_ednref10" title="" id="_ednref10">[10]</a> It appears that it’s not just how much we rest but also that the rhythm and regular cycles of that rest are important. These affect gene expression. Appropriate rest is essential during times of increased stress.<br />  <br /><strong>Vitamin D regulatesmore thantwothousand genes</strong><br /> Dr. Holick of Boston University states, “Every tissue and cell has a vitamin D receptor.  We estimate that as many as 2,000 genes—up to one-sixth of the total human genome—are directly or indirectly regulated by vitamin D.”<a href="#_edn11" name="_ednref11" title="" id="_ednref11">[11]</a> So get some sunlight and take your vitamin D supplements!<br />  <br /> Lifestyle medicine specialists and other health professionals trained in the latest vitamin D research recommend that each of us have our vitamin D (25[OH]D) blood test done twice a year and adjust our vitamin D supplement in order to achieve a vitamin D blood level of 50–100 ng/dl. Simply trying to estimate vitamin D blood levels is very inaccurate. Nine out of ten people have blood levels well below 50 ng/dl and therefore are at increased risk for many diseases. Don’t hesitate! Get tested before starting supplemental vitamin D. This baseline testing will help verify the true levels of those who think they have an acceptable level. Repeat the testing in the fall when the vitamin D blood levels are the highest due to the summer sunshine. Test again in the spring when the levels are typically at the lowest point.<br />  <br /><strong>What can I do tochange my gene expressions?</strong><br /><a>A Harvard study</a><a href="#_msocom_1" id="_anchor_1" name="_msoanchor_1">[TL1]</a>  states that sugar-sweetened soft drinks, processed meat, refined grains, and diet soft drinks are significantly correlated with inflammation.<a href="#_edn12" name="_ednref12" title="" id="_ednref12">[12]</a>Sweets and pastries are strongly associated with the highest levels of inflammation in the blood as measured by the lab test Cardiac CRP. Clinical specialists are now recognizing that an elevated Cardiac CRP is an important health risk factor for heart disease, diabetes, kidney disease, nerve damage, cancer, and autoimmune disease. Inflammation is thought to be the primary trigger to activate cancer, diabetes, and other catastrophic disease genes.<br />  <br /><strong>Lovingmothercuddlesimpactbabies’ genes</strong><br /> When a mother rat spends time licking, grooming, and nursing her babies, her offspring grow to be calm adults. But little rats who were not lovingly nurtured grow up to be nervous and anxious. Canadian researchers found that the presence or absence of nurturing love affected the part of the brain thatcontrols the level of stress hormone cortisol released by the adrenal glands and influenced the expression of receptor genes in the brain.<a href="#_edn13" name="_ednref13" title="" id="_ednref13">[13]</a><br />  <br /> Cortisol requires tight regulation. Too much leads to high blood pressure, spiking blood sugars, weight gain, emotional distress, and immune suppression. Too little leads to fatigue, unhealthfully low blood pressures, low blood sugars, memory lapses, and risk of autoimmune disease. Every healthy lifestyle habit we follow adds its influence to a more balanced cortisol production and the stability of the adrenal glands. The hardiness and vitality of our adrenals is often the determining factor in our ability to survive a traumatic injury, illness, or near-death experience. The above study suggests that we should make sure we get our healthy quota of hugs each day. Have you shared a caring hug with others in your family today?<br />  <br /><strong>If what’s true for rats holds true for humans . . .</strong><br /><em>Moms and dads</em>, hold and lovingly care for your babies. Why should they grow up to be nervous and deprived of cuddles when they are free? And why not continue to meet your child’s emotional needs and be loving beyond infancy and through the formative parts of their lives?<br />  <br /><strong>More thanjustbiologicalfactors</strong><br /> Notice that Dr. Ornish included stress reduction and a support group in his treatment of men with prostate cancer. But there is more that contributes to a healthy life. The Good Book says, “A merry heart does good, like medicine,” and “As a man thinks in his heart, so is he.”<a href="#_edn14" name="_ednref14" title="" id="_ednref14">[14]</a> What we think, how we think, and what we say and do are undoubtedly powerful determinants that turn genes offand on. Powerful determinants also include: Do we love unselfishly or do we hate? Are we pessimistic or optimistic in our attitudes? Are we hopeful or hopeless? Are we forgiving or bitter?<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 18</strong><br /> Diagram showing the Synergy Effect of the various factors in the WIN! model.<br />  </p> <p> <br /> We don’t doubt that soon scientific experiments will show that water intake, sunlight, fresh air, and certainly their combined impact positively affect gene expression. There is a <em>synergy </em>among all the life-giving factors of the WIN! Wellness model—the body, mind-spirit, and relationship dimensions. When one integrates all these dimensions in a balanced lifestyle, as shown in the diagram, the combined impact is immeasurably greater than by just employing one factor such as diet or exercise.<br />  <br /> As shown in the next diagram, these factors not only have a synergistic effect (synergy means that the whole is greater than the sum of its parts), but as they blend together there is a transformation of genetic expression.  There is an unlocking of the genes of health and healing.  The result, as the arrow indicates, is a dynamite, victorious NEW YOU!<br />  </p> <p> <strong>PowerPoint© Slide 19</strong><br /><strong>Diagram showing how the various WIN! Wellness factors blend and work out a transformation of genetic expression.</strong></p> <p> <br /> Most or all of us have cancer genes. But whether or not one of those genes is turned on depends in a great degree on you and me—on ourchoices, the food we eat, whether or not we exercise, whether we sleep sufficient hours, the amount of water we drink—ourlifestyle. I am the one who throws the switch. Nature has endowed us with checks and balances. We also have genes that, if turned on, protect us against cancer. This is where our self-discipline or lack of self-discipline comes in. Do I actually put into practice those habits which will make me a healthier person? Perseverance in a good lifestyle will determine, to a great degree, if these protective genes are switched on or off.<br />  <br /> The expression of most genes is affected by lifestyle and environmental factors and other influences. However, it is also true that some individuals have lived a healthy lifestyle and still fall ill with some dread diseases such as heart disease, arthritis, or cancer. Sickness should not generate guilt that the ill person has lived unhealthfully. There are environmental exceptions and other influences that we don’t always understand.<br />  <br /><strong>Mind-spiritandwholepersonimplications</strong><br /> Some people blame their parents for their bad traits of character and habits. Parents may have been negligent, but when we have passed childhood, it’s time to square our shoulders, look the world in the face and say, “Whatever my past may have been, I am now the architect of my character, I am the master of my fate.” The same is true of our health. Choices were God’s gift to us at Creation, and they have health and even eternal consequences. We shape our lives for good or bad by our choices.<br />  <br /> Some people blame God for their problems in life. This is a false accusation. If God were in the business of forcing people’s will and determining their destiny, then He could have overruled and made Adam and Eve so they could not sin and could do only right things. But God did not create robots; He created human beings in His own image,who can think and do that which prevents disease. They can choose their own destiny. God values free will, and when the human race went wrong by disobeying Him, He showed us by His love the way back through giving His Son to die for us.<br />  <br /> Actually, God is about prevention of disease and not just damage control. He encourages us to make right choices—to follow the health laws so we can be healthy and free of disease. All of us need to study and research current information on prevention and to turn offbad genes. The next step is to apply it to our lifestyle.<br />  <br /> We have a great opportunity, even to change our destiny. We have choices set before us whereby we may “be transformed by the renewing of [our] mind.”<a href="#_edn15" name="_ednref15" title="" id="_ednref15">[15]</a> When we have a new mind, it will transform our thinking and our health.<br />  <br /><strong>Are weslavesofhereditarytendencies?</strong><br /> A book from a century ago called <em>The </em><em>Ministry of Healing<a href="#_edn16" name="_ednref16" title="" id="_ednref16"><strong>[16]</strong></a></em> states:</p> <p>  </p> <p> <strong>PowerPoint© Slide 20</strong><br />  <br />  “Those who put their trust in Christ are not to be enslaved by any <em>hereditary</em> or <em>cultivated</em> habit or tendency. Instead of being held in bondage to the lower nature, they are to rule every appetite and passion.</p> <p>  </p> <p> <strong>PowerPoint© Slide 21</strong><br />  <br /> God has not left us to battle with evil in our own finite strength. Whatever may be our <em>inherited</em> or <em>cultivated tendencies</em> to wrong, we can overcome through the power that He is ready to impart.</p> <p> </p> <p>  </p> <p> <strong>PowerPoint© Slide 22</strong><br /><strong>You can Choose a New Direction</strong><br /> “Everything depends on the right action of the will. . . Through the right exercise of the will an entire change may be made in the life.”</p> <p> <br /> If you believe that total victory is possible, you are well on your way to claiming that victory.<br />  <br /><strong>Weare wonderfully made</strong><br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 23</strong><br /> Humans have about 25,000 <em>genes</em>. </p> <p> <br /> Your genes are unique to you, unless you are an identical twin or multiple. If the human genome were compiled in books, the equivalent of two-hundredvolumes the size of a Manhattan telephone book would be needed to hold it all, and it would take nine and a half years to read it aloud without stopping. Wow! Your body is complicated, isn’t it?<br />  <br /> Humans are given a set of genes at birth. We are now recognizing the power of lifestyle choices to influence how those genes behave. We have been given the power of choice. These choices have been shown to turn genes onand off. Our choices largely determine our future health or illness.<br />  <br /><strong>Breakingthechain</strong><br /> Recent news reports said that scientists had identified the “infidelity gene.” What does that mean? If I have that gene, does that determine whether I’m going to cheat on my wife? Nonsense! Even if that were in my <em>genome</em>, I still have an <em>epigenome</em> and I am the one who throws the switch onor off, determining how that gene expresses itself, which decides whetherI will be faithful or unfaithful to my spouse.<br />  <br /> Here is good news for you. There is <em>hope!</em> Maybe your grandfather was dishonest. Maybe your great-grandmother was a smoker and an angry person, or your dad had heart problems and your mother had breast cancer. Maybe a chain of problems has appeared for generation after generation and your ancestry has been characterized by anger, resentment, robbery, lying, immorality, drinking, drug problems, mediocrity, rejection—and we could add diabetes, obesity, high cholesterol, or high blood pressure. That doesn’t lock you in! You can receive strength from above and choose to throw the switch.<br />                                                                                                          </p> <p>  </p> <p> <strong>PowerPoint© Slide 24</strong><br /><em>Chains of slavery being broken on Caribbean island of Cura</em>çao.</p> <p> <br />  <br /> On a beach in the Caribbean island of Caraçao there is a sculpture depicting the moment in 1863 when the slaves were freed. A liberator stands, chisel and hammer in his hands, “breaking the chain.” Do you choose to ask the Divine Liberator to break your chains?<br />  <br /> In the freedom chapter we will establish how we can celebrate freedom from drug and other behavioral addictions. The good news is that we can break <em>every</em> chain, whether it is cultivated by past actions or received by heredity. Someone is ready to break our chains if we choose to let Him do it. God will deliver us from the captivity of genetic tendencies and fate. He is there to help us make good choices. If we are willing, we can <em>live</em>—live longer, healthier, happier, and holier. God can break the chain. If you’re in a personal prison, don’t despair! The key is in your pocket! It’s your choice!<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 25</strong><br /><strong>Prayer</strong><br /><em>ThankYou, Lord, thatalthoughour genes are passeddowntousfromourparents, Youhave made a wayforustoturnoffbad genes andturnongoodones. </em><br />  </p> <p> <br />  <br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 26</strong><br /><em>ThankYouthatwe are notslavesoffate, butwe can choosethepowerthat comes fromYouand can haveheavenlyhelp in conqueringdiseaseandcharacterweakness. Weacceptthatpowernow. In Jesus’ name, amen.</em><br />  </p> <p> <br /><strong>Reflect/Discuss</strong><br />  </p> <p>  </p> <p>  <br /><strong>PowerPoint© Slide 27</strong><br /><strong>Group Discussion</strong></p> <ol><li> What “good genes” do you think you have inherited from your parents?__________________</li> <li> What additional “good genes” is it your desire to inherit from your Heavenly Father? _____________.</li> </ol><p> <br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 28</strong><br /> 3.  Do you know anyonewhoreceived a legacyofvarious “bad genes” whochose a differentpathand made a contributiontosociety?  What made thedifference?Share.</p> <p> <br />  <br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 29</strong><br /><strong>Personal Reflection</strong></p> <ol><li> Am I knowledgeable about health and character tendencies that I may have received from past generations? What do I know about the health of my past relatives?</li> </ol><p>  </p> <p> <br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 30</strong><br /><strong>Personal Reflection</strong></p> <ol><li value="2"> What additional “good genes” do you desire that your children inherit from you?</li> </ol><p>  </p> <p> <br />  <br /><strong>Personal Reflection</strong><br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 31</strong><br /><strong>Intentionality</strong><br />       1. One genetic or hereditary tendency I want to break in my family chain is<br />  </p> <p> <br />  <br />  <br />  <br />  <br />  <br />  <br />  </p> <p> <strong></strong></p> <p> <br />  <br /><strong>Am I turningthegood genes onby</strong><br /> r   exercising 30–60 minutes five to seven days a week?<br /> r   eating a good nutritious plant-based diet?<br /> r   getting sufficient rest of eight hours?<br /> r   getting appropriate sunlight or vitamin D supplements?<br /> r   inhaling lots of fresh air?<br /> r   drinking six to eight glasses of water a day?<br /> r   being positive?<br /> r   using stress management techniques?<br />  <br />  <br /> In Matthew 9:29 we read:<br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 33</strong><br /><strong>Promises</strong><br /> Jesus said:  “According to your faith, be it onto you.”  Thank You, Lord, for promising me the victory.  I claim it now by Your power.  “I can do all things through Christ who strengthens me”<br /><em>Philippians 4:13</em>.<br /> Signed____________________________ Date________________<br />  </p> <p> <br />  <br />  </p> <p>  </p> <p> <strong>PowerPoint© Slide 34</strong><br /><strong>“But I’ve Got Bad Genes!”</strong><br /><em>The End</em></p> <p> </p> <p> <a href="#_ednref1" name="_edn1" title="" id="_edn1">[1]</a>. “Epigenetics,” <em>Nova Science Now</em>, aired July 24, 2007, directed by Samantha Holt, transcript, <a href="http://www.pbs.org/wgbh/nova/body/epigenetics.html">http://www.pbs.org/wgbh/nova/body/epigenetics.html</a>.</p> <p> <a href="#_ednref2" name="_edn2" title="" id="_edn2">[2]</a>. “Cytosine methylations at regions of gene promoters rich in CpG islands are generally associated with the silencing of genes, whereas histone acetylations are generally associated with the activation of genes.” George M. Martin, “Epigenetic Drift in Aging Identical Twins,” <em>Proceedings of the National Academy of Sciences</em> 102, no. 30 (2005): 10413–10414, <a href="http://www.pnas.org/content/102/30/10413">http://www.pnas.org/content/102/30/10413</a>. dio:10.1073/pnas.0504743102.</p> <p> <a href="#_ednref3" name="_edn3" title="" id="_edn3">[3]</a>. Martin, “Epigenetic Drift.”</p> <p> <a href="#_ednref4" name="_edn4" title="" id="_edn4">[4]</a>. John Kelly, “Your Genes Are Not Your Destiny,” presentation, International Coronary Health Improvement Program (CHIP) Summit, Loma Linda, California, November 19, 2010. DVD available from Adventist CHIP Association, 247 Peach Orchard Rd., Greeneville TN 37745.</p> <p> <a href="#_ednref5" name="_edn5" title="" id="_edn5">[5]</a>. Ethan Watters, “DNA Is Not Destiny,” <em>Discover Magazine</em>, November 2006, <a href="http://discovermagazine.com/2006/nov/cover">http://discovermagazine.com/2006/nov/cover</a>, emphasis supplied.</p> <p> <a href="#_ednref6" name="_edn6" title="" id="_edn6">[6]</a>. Dean Ornish, Mark Jesus M. Magbanua, Gerdi Weidner, Vivian Weinberg, Colleen Kemp, Christopher Green,<br /> Michael D. Mattie, Ruth Marlin, Jeff Simko, Katsuto Shinohara, Christopher M. Haqq, and Peter R. Carroll, “Changes in Prostate Gene Expression in Men Undergoing an Intensive Nutrition and Lifestyle Intervention,” <em>Proceedings of the National Academy of Sciences</em> 105, no. 24 (2008): 8369–8374. </p> <p> <a href="#_ednref7" name="_edn7" title="" id="_edn7">[7]</a>. Dean Ornish, MD, “Changing Your Lifestyle Can Change Your Genes,” <em>Prostate Cancer Communication</em>, June 2011, 20.</p> <p> <a href="#_ednref8" name="_edn8" title="" id="_edn8">[8]</a>. “Shine On Award Winners: Pioneer: Elizabeth Blackburn,” <em>Good Housekeeping</em>, May 2011, 104.</p> <p> <a href="#_ednref9" name="_edn9" title="" id="_edn9">[9]</a>. Kelly, “Your Genes Are Not Your Destiny.”</p> <p> <a href="#_ednref10" name="_edn10" title="" id="_edn10">[10]</a>. Allen Institute for Brain Science, “Specific changes in the brain associated with sleep deprivation described in new study,”PhysOrg.com (blog), Nov. 3, 2010 <a href="http://www.physorg.com/news/2010-11-specific-brain-deprivation.html">http://www.physorg.com/news/2010-11-specific-brain-deprivation.html</a> . .</p> <p> <a href="#_ednref11" name="_edn11" title="" id="_edn11">[11]</a>. <a href="http://www.bu.edu/today/2010/sunny-dispositions-and-vitamin-d/">www.bu.edu/today/2010/sunny-dispositions-and-vitamin-d/</a> . Retrieved 03-14-2012. Interview with Barbara Gilchrest and Michael Holick, School of Medicine, Boston University.</p> <p> <a href="#_ednref12" name="_edn12" title="" id="_edn12">[12]</a> . Matthias B. Schulze, Kurt Hoggmann, et al, “Dietary Pattern, Inflammation, and Incidence of Type 2 Diabetes in Women,” <em>American Journal of Clinical Nutrition</em> 82, no. 3 (September 2005): 675-715, <a href="http://www.ajcn.org/content/82/3/675.full.pdf+html">http://www.ajcn.org/content/82/3/675.full.pdf+html</a>.</p> <p> <a href="#_ednref13" name="_edn13" title="" id="_edn13">[13]</a>. Associated Press, “Animal Study Indicates Maternal Care Influences Later Psychological Health,”<br /> June 11, 2003, <a href="http://www.hscareers.com/news/articles.asp?id=474">http://www.hscareers.com/news/articles.asp?id=474</a>.</p> <p> <a href="#_ednref14" name="_edn14" title="" id="_edn14">[14]</a>. Proverbs 17:22; paraphrase of Proverbs 23:7.</p> <p> <a href="#_ednref15" name="_edn15" title="" id="_edn15">[15]</a>. Romans 12:2. Note: earlier verses talk about having the “mind of the Lord” (Rom. 11:34) and presenting our “bodies a living sacrifice” (Rom. 12:1). The word <em>transformed</em> comes from the Greek word <em>metamorphoo</em>, from which we get the English word <em>metamorphosis</em>—changed like the metamorphosis of a caterpillar worm to a chrysalis to a butterfly.</p> <p> <a href="#_ednref16" name="_edn16" title="" id="_edn16">[16]</a> White, <em>The Ministry of Healing, </em>175, 176. Italics supplied.</p> <p>  <a href="#_msoanchor_1">[TL1]</a>Source?</p> <p> </p>

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